Chlormezanone
Tocris Bioscience, part of Bio-Techne | Catalog # 0456
Positive allosteric modulator of benzodiazepine site
Key Product Details
Description
Positive allosteric modulator of benzodiazepine site
Product Description
Chlormezanone is a anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABAA receptors.Product Specifications
Molecular Weight
273.73
Formula
C11H12ClNO3S
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one-1,1-dioxide
CAS Number
80-77-3
PubChem ID
2717
InChI Key
WEQAYVWKMWHEJO-UHFFFAOYSA-N
SMILES
CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.37 | 100 | |
| Ethanol | 6.84 | 25 |
Preparing Stock Solutions
for Chlormezanone
The following data is based on the product molecular weight 273.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.27 mL | 36.53 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.31 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Simiand Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 1989 PMID: 2567153
- Ervin and Cooper Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 1988 PMID: 2896235
Product Specific Notices for Chlormezanone
For research use only
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