Chlormezanone

Name: Chlormezanone
Brand: Tocris Bioscience
SKU: 0456

Tocris Bioscience, part of Bio-Techne | Catalog # 0456

Citations (2)

COA / SDS

Positive allosteric modulator of benzodiazepine site

Key Product Details

Description:	Positive allosteric modulator of benzodiazepine site
Chemical Name:	2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one-1,1-dioxide
Purity:	≥99% (HPLC)
Molecular Weight:	273.73

View Full Technical Details for Chlormezanone

Technical Data
Citations

Biological Activity for Chlormezanone

Chlormezanone is a anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABA_A receptors.

Compound Libraries for Chlormezanone

Chlormezanone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Chlormezanone

M. Wt	273.73
Formula	C₁₁H₁₂ClNO₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	80-77-3
PubChem ID	2717
InChi Key	WEQAYVWKMWHEJO-UHFFFAOYSA-N
Smiles	CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chlormezanone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.37	100
	ethanol	6.84	25

Preparing Stock Solutions for Chlormezanone

The following data is based on the product molecular weight 273.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.27 mL	36.53 mL
5 mM	0.73 mL	3.65 mL	7.31 mL
10 mM	0.37 mL	1.83 mL	3.65 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

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References for Chlormezanone

References are publications that support the biological activity of the product.

Simiand Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 1989 PMID: 2567153
Ervin and Cooper Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 1988 PMID: 2896235