Chlormezanone

Name: Chlormezanone
Brand: tocris
SKU: 0456

Catalog # 0456

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	Positive allosteric modulator of benzodiazepine site
Chemical Name:	2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one-1,1-dioxide
Purity:	≥99% (HPLC)
Molecular Weight:	273.73

View Full Technical Details for Chlormezanone

Biological Activity

Chlormezanone is a anxiolytic and skeletal muscle relaxant that acts at the benzodiazepine site of GABA_A receptors.

Compound Libraries

Chlormezanone is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	273.73
Formula	C₁₁H₁₂ClNO₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	80-77-3
PubChem ID	2717
InChi Key	WEQAYVWKMWHEJO-UHFFFAOYSA-N
Smiles	CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.37	100
	ethanol	6.84	25

Preparing Stock Solutions

The following data is based on the product molecular weight 273.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.65 mL	18.27 mL	36.53 mL
5 mM	0.73 mL	3.65 mL	7.31 mL
10 mM	0.37 mL	1.83 mL	3.65 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Ervin and Cooper Use of conditioned taste aversion as a conflict model: effects of anxiolytic drugs. J.Pharmacol.Exp.Ther. 1988 PMID: 2896235
Simiand Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants. Arch.Int.Pharmacodyn.Ther. 1989 PMID: 2567153
Merck Index