CH 223191

Tocris Bioscience, part of Bio-Techne | Catalog # 3858

Potent aryl hydrocarbon receptor (AhR) antagonist
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Key Product Details

Description

Potent aryl hydrocarbon receptor (AhR) antagonist

View all Aryl Hydrocarbon Receptor Antagonists »

Product Description

CH 223191 is a potent aryl hydrocarbon receptor (AhR) antagonist (IC50 = 30 nM). Exhibits no AhR agonist-like activity (at concentrations up to 100 μM). Inhibits 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced AhR-dependent transcription in vitro and reduces TCDD-induced toxicity in vivo. Attenuates Th17 differentiation of naive CD4 T cells and promotes expansion of hematopoietic stem cells in vitro.

Product Specifications

Molecular Weight

333.39

Formula

C19H19N5O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide

CAS Number

301326-22-7

PubChem ID

3091786

InChI Key

LKTNEXPODAWWFM-UHFFFAOYSA-N

SMILES

CC1=C(/N=N/C2=CC=C(NC(C3=CC=NN3C)=O)C(C)=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.34 100

Preparing Stock Solutions for CH 223191

The following data is based on the product molecular weight 333.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.00 mL 15.00 mL 29.99 mL
5 mM 0.60 mL 3.00 mL 6.00 mL
10 mM 0.30 mL 1.50 mL 3.00 mL
50 mM 0.06 mL 0.30 mL 0.60 mL

Calculators

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Product Documents for CH 223191

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CH 223191

For research use only

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