CGS 35066

Tocris Bioscience, part of Bio-Techne | Catalog # 2512

Endothelin-converting enzyme (ECE) inhibitor
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Key Product Details

Description

Endothelin-converting enzyme (ECE) inhibitor

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Product Description

CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Product Specifications

Molecular Weight

349.28

Formula

C16H16NO6P

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid

CAS Number

261619-50-5

PubChem ID

9863167

InChI Key

CRUVAUSVWLATAE-ZDUSSCGKSA-N

SMILES

O=C([C@@H](NCP(O)(O)=O)CC1=CC3=C(C2=CC=CC=C2O3)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 34.92 100

Preparing Stock Solutions for CGS 35066

The following data is based on the product molecular weight 349.28

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CGS 35066

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGS 35066

For research use only

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