CGS 21680 hydrochloride
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | A2A agonist |
Chemical Name: | 4-[2-[[6-Amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 535.99 |
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Citations for CGS 21680 hydrochloride (75)
Citations are publications that use Bio-Techne products. Selected citations for CGS 21680 hydrochloride include:
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Xu et al.
(2022)
Adenosine A2A receptors control synaptic remodeling in the adult brain.
Sci Rep.
12:14690
PMID: 36038626 -
Monticone et al.
(2022)
Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.
Front.Immunol..
13:987298
PMID: 36090975 -
Nuccio et al.
(2019)
Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes.
Sci Rep.
9:9782
PMID: 31278313 -
Kong et al.
(2019)
Adenosine A2a receptor agonist CGS21680 treatment attenuates cardiopulmonary bypass-associated inflammatory lung injury in juvenile rats.
Mol.Med.Rep..
20:117
PMID: 31115565 -
Núñez et al.
(2018)
PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders.
Front Pharmacol.
9:1200
PMID: 30405415 -
Shifrut et al.
(2018)
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.
Cell.
175:1958
PMID: 30449619 -
Jain et al.
(2018)
Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
Am J Physiol Endocrinol Metab.
315:E357
PMID: 29812984 -
Bakhshayesh et al.
(2017)
The Mediating Role of A2A Adenosine Receptors in the Mitochondrial Pathway of Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat.
Basic Clin Neurosci.
8:317
PMID: 29158882 -
Caiazzo et al.
(2016)
Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Biochem.Pharmacol..
112:72
PMID: 27188793 -
Ledderose et al.
(2016)
Adenosine arrests breast cancer cell motility by A3 receptor stimulation.
Purinergic Signalling.
2016;
PMID: 27577957 -
Liu et al.
(2016)
Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome.
Scientific Reports.
6:33614
PMID: 27647162 -
Perez-Aso et al.
(2015)
Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors.
Arthritis Res Ther.
17:249
PMID: 26370839 -
Eusemann et al.
(2015)
Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells.
PLoS One.
10:e0134934
PMID: 26263491 -
Kermanian et al.
(2015)
Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity.
Eneuro.
28:120
PMID: 25678999 -
Polito et al.
(2015)
Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Mol Cell Biol.
2
PMID: 26465004 -
Tosolini et al.
(2015)
Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death.
Psychopharmacology (Berl).
35:479
PMID: 25384972 -
Wydra et al.
(2015)
On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
Am J Respir Cell Mol Biol.
232:1767
PMID: 25420611 -
Kavanagh et al.
(2015)
Role of adenosine receptor subtypes in metha. reward and reinforcement.
J Neurogenet.
89:265
PMID: 25301277 -
Ferreira et al.
(2015)
Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission.
Br J Pharmacol.
172:1074
PMID: 25296982 -
Welihinda and Amento
(2014)
Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation.
J Inflamm (Lond).
11:37
PMID: 25473378 -
Ziemlinska et al.
(2014)
Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats.
PLoS One.
9:e88833
PMID: 24551172 -
Ahsan and Mehal
(2014)
Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb.
Front Pharmacol.
5:69
PMID: 24782773 -
Perígolo-Vicente et al.
(2014)
IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Biochem Biophys Res Commun.
449:477
PMID: 24845382 -
Li et al.
(2014)
Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.
Vis Neurosci.
31:237
PMID: 24844306 -
Ruby et al.
(2014)
Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light.
Kidney Int.
39:2432
PMID: 24755889 -
O'Neill et al.
(2014)
Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats.
Psychopharmacology (Berl).
231:3179
PMID: 24562064 -
Chen et al.
(2014)
Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat
J Neurosci.
34:9621
PMID: 25031403 -
Xiao et al.
(2013)
Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy.
PLoS One.
8:e60173
PMID: 23585831 -
He et al.
(2013)
Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.
FASEB J.
27:3446
PMID: 23682121 -
Thomas et al.
(2013)
Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies.
Bioorg Med Chem.
21:7453
PMID: 24126093 -
Matos et al.
(2013)
Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.
J Neurosci.
33:18492
PMID: 24259572 -
Wiseman et al.
(2013)
Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.
J Biol Chem.
288:17803
PMID: 23640883 -
Kozma et al.
(2013)
Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
Biochem Pharmacol.
85:1171
PMID: 23376019 -
Aggarwal et al.
(2013)
Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.
Neuropsychopharmacology.
48:635
PMID: 23349051 -
Fernández-Dueñas et al.
(2013)
DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.
FASEB J.
63:42
PMID: 23619397 -
Bao et al.
(2013)
Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils.
J Biol Chem.
288:22650
PMID: 23798685 -
Loram et al.
(2013)
Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
Brain Behav Immun.
33:112
PMID: 23811314 -
Garção et al.
(2013)
Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum.
Br J Pharmacol.
169:1600
PMID: 23638679 -
Yang et al.
(2013)
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
J Cereb Blood Flow Metab.
33:1612
PMID: 23860373 -
Lee
(2013)
Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice.
J Immunol.
191:4103
PMID: 24043903 -
Lee et al.
(2012)
When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?
PLoS One.
7:e38865
PMID: 22719969 -
Mediero et al.
(2012)
Adenosine A2A receptor activation prevents wear particle-induced osteolysis.
Sci Transl Med.
4:135ra65
PMID: 22623741 -
O'Neill et al.
(2012)
Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats.
Neuropsychopharmacology.
37:1245
PMID: 22169945 -
Kan et al.
(2012)
Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway.
J Virol.
86:10338
PMID: 22787201 -
Jeon et al.
(2012)
Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection.
Neurochem Int.
20:27
PMID: 24116271 -
Mills et al.
(2012)
Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis.
J Neurochem.
9:193
PMID: 22883932 -
Fernández-Dueñas et al.
(2012)
Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.
J Immunol.
123:373
PMID: 22924752 -
Park et al.
(2012)
Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.
Kidney Int.
82:878
PMID: 22695326 -
Hobson et al.
(2012)
Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats.
Neuropharmacology.
63:1172
PMID: 22749927 -
Carlström et al.
(2011)
Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase.
Am J Physiol Renal Physiol.
300:F457
PMID: 21106859 -
Su et al.
(2011)
Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes.
Cancer Immunol Immunother.
60:111
PMID: 20960188 -
Ru et al.
(2011)
Adenosine-induced activation of esophageal nociceptors.
Am J Physiol Gastrointest Liver Physiol.
300:G485
PMID: 21148396 -
Garcia et al.
(2011)
Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation.
PLoS One.
80:378
PMID: 21508927 -
Kiebala and Maggirwar
(2011)
Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells.
PLoS One.
6:e18633
PMID: 21494611 -
Hiranita et al.
(2010)
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
J Pharmacol Exp Ther.
332:515
PMID: 19892920 -
Garavaglia et al.
(2010)
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
BMC Neurosci.
11:7
PMID: 20085655 -
Zhou et al.
(2010)
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
J Clin Invest.
120:2280
PMID: 20516643 -
Gebremedhin et al.
(2010)
Adenosine can mediate its actions through generation of reactive oxygen species.
J Cereb Blood Flow Metab.
30:1777
PMID: 20531463 -
Das et al.
(2010)
Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists.
J Nanobiotechnology.
8:11
PMID: 20478037 -
Keene et al.
(2010)
Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor.
Biochem Pharmacol.
80:188
PMID: 20346920 -
Higley and Sabatini
(2010)
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Nat Neurosci.
13:958
PMID: 20601948 -
Wang et al.
(2010)
Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385.
Biomol Ther (Seoul).
5:e13883
PMID: 21079735 -
Nowak et al.
(2010)
The A2aR adenosine receptor controls cytokine production in iNKT cells.
Neuropharmacology.
40:682
PMID: 20039304 -
Epperson et al.
(2009)
Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts.
Am J Physiol Cell Physiol.
296:C1171
PMID: 19244482 -
Xi et al.
(2009)
Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts.
J Mol Cell Cardiol.
47:684
PMID: 19695259 -
Ohta et al.
(2009)
A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments.
Eur J Immunol.
183:5487
PMID: 19843934 -
Pugliese et al.
(2009)
The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.
Br J Pharmacol.
157:818
PMID: 19422385 -
Shen et al.
(2008)
Dichotomous DArgic control of striatal synaptic plasticity.
Science.
321:848
PMID: 18687967 -
Garcia et al.
(2008)
Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.
J Neuroinflammation.
22:445
PMID: 17898087 -
Yang et al.
(2006)
The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.
J Clin Invest.
116:1913
PMID: 16823489 -
Keir et al.
(2006)
Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.
Br J Pharmacol.
147:720
PMID: 16432507 -
Kornerup et al.
(2005)
Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge.
Br J Pharmacol.
144:1011
PMID: 15685200 -
Germack and Dickenson
(2004)
Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes.
Br J Pharmacol.
141:329
PMID: 14751870 -
Nieri et al.
(2001)
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
Br J Pharmacol.
134:745
PMID: 11606314 -
Ezeamuzie and Philips
(1999)
Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release.
Br J Pharmacol.
127:188
PMID: 10369472
There are no citations that match your criteria.
Customer Reviews for CGS 21680 hydrochloride (2)
Customer Images
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Species: HumanAssay Type: In VitroHEK cell line expressing A2A Receptor were treated with CGS in presence or absence of ZM241385 for 30 minutes and level of cAMP was measured.
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Species: MouseAssay Type: In VitroWorks perfectly on my CD4 T cells proliferation assay, when detected by CFSE. It inhibited the proliferation of activated CD4 cells in dose-dependent manner.
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