CGS 21680 hydrochloride

Citations are publications that use Bio-Techne products. Selected citations for CGS 21680 hydrochloride include:

• Nuccio et al. (2019) Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes. Sci Rep. 9:9782
  PMID: 31278313
• Jain et al. (2018) Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 315:E357
  PMID: 29812984
• Shifrut et al. (2018) Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Cell. 175:1958
  PMID: 30449619
• Núñez et al. (2018) PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders. Front Pharmacol. 9:1200
  PMID: 30405415
• Bakhshayesh et al. (2017) The Mediating Role of A2A Adenosine Receptors in the Mitochondrial Pathway of Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat. Basic Clin Neurosci. 8:317
  PMID: 29158882
• Ledderose et al. (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling. 2016;
  PMID: 27577957
• Liu et al. (2016) Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Scientific Reports. 6:33614
  PMID: 27647162
• Caiazzo et al. (2016) Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem.Pharmacol.. 112:72
  PMID: 27188793
• Wydra et al. (2015) On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats. Am J Respir Cell Mol Biol. 232:1767
  PMID: 25420611
• Ferreira et al. (2015) Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. Br J Pharmacol. 172:1074
  PMID: 25296982
• Kavanagh et al. (2015) Role of adenosine receptor subtypes in metha. reward and reinforcement. J Neurogenet. 89:265
  PMID: 25301277
• Tosolini et al. (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Psychopharmacology (Berl). 35:479
  PMID: 25384972
• Polito et al. (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Mol Cell Biol. 2
  PMID: 26465004
• Kermanian et al. (2015) Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity. Eneuro. 28:120
  PMID: 25678999
• Perez-Aso et al. (2015) Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 17:249
  PMID: 26370839
• Eusemann et al. (2015) Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS One. 10:e0134934
  PMID: 26263491
• Perígolo-Vicente et al. (2014) IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun. 449:477
  PMID: 24845382
• Chen et al. (2014) Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential regulat J Neurosci. 34:9621
  PMID: 25031403
• O'Neill et al. (2014) Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats. Psychopharmacology (Berl). 231:3179
  PMID: 24562064
• Ruby et al. (2014) Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. Kidney Int. 39:2432
  PMID: 24755889
• Li et al. (2014) Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci. 31:237
  PMID: 24844306
• Welihinda and Amento (2014) Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 11:37
  PMID: 25473378
• Ahsan and Mehal (2014) Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb. Front Pharmacol. 5:69
  PMID: 24782773
• Ziemlinska et al. (2014) Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One. 9:e88833
  PMID: 24551172
• Loram et al. (2013) Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain Behav Immun. 33:112
  PMID: 23811314
• Yang et al. (2013) Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet. J Cereb Blood Flow Metab. 33:1612
  PMID: 23860373
• Bao et al. (2013) Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 288:22650
  PMID: 23798685
• Lee (2013) Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. J Immunol. 191:4103
  PMID: 24043903
• Thomas et al. (2013) Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies. Bioorg Med Chem. 21:7453
  PMID: 24126093
• Fernández-Dueñas et al. (2013) DA D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. FASEB J. 63:42
  PMID: 23619397
• Garção et al. (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol. 169:1600
  PMID: 23638679
• He et al. (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 27:3446
  PMID: 23682121
• Xiao et al. (2013) Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. PLoS One. 8:e60173
  PMID: 23585831
• Aggarwal et al. (2013) Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Neuropsychopharmacology. 48:635
  PMID: 23349051
• Matos et al. (2013) Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes. J Neurosci. 33:18492
  PMID: 24259572
• Kozma et al. (2013) Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 85:1171
  PMID: 23376019
• Wiseman et al. (2013) Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase. J Biol Chem. 288:17803
  PMID: 23640883
• Park et al. (2012) Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 82:878
  PMID: 22695326
• Mediero et al. (2012) Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med. 4:135ra65
  PMID: 22623741
• Lee et al. (2012) When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders? PLoS One. 7:e38865
  PMID: 22719969
• Kan et al. (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 86:10338
  PMID: 22787201
• O'Neill et al. (2012) Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology. 37:1245
  PMID: 22169945
• Fernández-Dueñas et al. (2012) Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R. J Immunol. 123:373
  PMID: 22924752
• Hobson et al. (2012) Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to DA D2 receptors in rats. Neuropharmacology. 63:1172
  PMID: 22749927
• Jeon et al. (2012) Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection. Neurochem Int. 20:27
  PMID: 24116271
• Mills et al. (2012) Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis. J Neurochem. 9:193
  PMID: 22883932
• Kiebala and Maggirwar (2011) Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS One. 6:e18633
  PMID: 21494611
• Garcia et al. (2011) Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. PLoS One. 80:378
  PMID: 21508927
• Su et al. (2011) Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes. Cancer Immunol Immunother. 60:111
  PMID: 20960188
• Ru et al. (2011) Adenosine-induced activation of esophageal nociceptors. Am J Physiol Gastrointest Liver Physiol. 300:G485
  PMID: 21148396
• Carlström et al. (2011) Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol. 300:F457
  PMID: 21106859
• Zhou et al. (2010) GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 120:2280
  PMID: 20516643
• Higley and Sabatini (2010) Competitive regulation of synaptic Ca²⁺ influx by D2 DA and A2A adenosine receptors. Nat Neurosci. 13:958
  PMID: 20601948
• Garavaglia et al. (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 11:7
  PMID: 20085655
• Nowak et al. (2010) The A2aR adenosine receptor controls cytokine production in iNKT cells. Neuropharmacology. 40:682
  PMID: 20039304
• Keene et al. (2010) Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol. 80:188
  PMID: 20346920
• Das et al. (2010) Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists. J Nanobiotechnology. 8:11
  PMID: 20478037
• Wang et al. (2010) Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. Biomol Ther (Seoul). 5:e13883
  PMID: 21079735
• Gebremedhin et al. (2010) Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab. 30:1777
  PMID: 20531463
• Hiranita et al. (2010) Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine. J Pharmacol Exp Ther. 332:515
  PMID: 19892920
• Epperson et al. (2009) Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 296:C1171
  PMID: 19244482
• Pugliese et al. (2009) The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol. 157:818
  PMID: 19422385
• Ohta et al. (2009) A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments. Eur J Immunol. 183:5487
  PMID: 19843934
• Xi et al. (2009) Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 47:684
  PMID: 19695259
• Shen et al. (2008) Dichotomous DArgic control of striatal synaptic plasticity. Science. 321:848
  PMID: 18687967
• Garcia et al. (2008) Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. J Neuroinflammation. 22:445
  PMID: 17898087
• Yang et al. (2006) The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 116:1913
  PMID: 16823489
• Keir et al. (2006) Mechanism of adenosine-induced airways obstruction in allergic guinea pigs. Br J Pharmacol. 147:720
  PMID: 16432507
• Kornerup et al. (2005) Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol. 144:1011
  PMID: 15685200
• Germack and Dickenson (2004) Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 141:329
  PMID: 14751870
• Nieri et al. (2001) Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. Br J Pharmacol. 134:745
  PMID: 11606314
• Ezeamuzie and Philips (1999) Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release. Br J Pharmacol. 127:188
  PMID: 10369472

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• works on inhibited CD4 cells

  Name: Anonymous
  Species: Mouse
  Assay Type: In Vitro
  Works perfectly on my CD4 T cells proliferation assay, when detected by CFSE. It inhibited the proliferation of activated CD4 cells in dose-dependent manner.
  

• Cell based assays

  Name: Anonymous
  Species: Human
  receptors, antibody or ILISA Kits
  HGF protein

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