CGS 19755

Name: CGS 19755
Brand: Tocris Bioscience
SKU: 1241

Catalog # 1241 | Tocris Bioscience a Bio-Techne Brand

Citations (4)

COA / SDS

Potent competitive NMDA antagonist

Key Product Details

Description:	Potent competitive NMDA antagonist
Chemical Name:	cis-4-[Phosphomethyl]-piperidine-2-carboxylic acid
Molecular Weight:	223.17

View Full Technical Details for CGS 19755

Technical Data
Citations (4) / Reviews

Biological Activity for CGS 19755

CGS 19755 is a potent, competitive NMDA receptor antagonist. Anticonvulsant and neuroprotective.

Technical Data for CGS 19755

M. Wt	223.17
Formula	C₇H₁₄NO₅P
Storage	Store at RT
CAS Number	110347-85-8
PubChem ID	6604838
InChi Key	LPMRCCNDNGONCD-NTSWFWBYSA-N
Smiles	O=P(C[C@@H]1C[C@H]([C@](O)=O)NCC1)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGS 19755

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.58	25

Preparing Stock Solutions for CGS 19755

The following data is based on the product molecular weight 223.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	17.92 mL	89.62 mL	179.24 mL
1.25 mM	3.58 mL	17.92 mL	35.85 mL
2.5 mM	1.79 mL	8.96 mL	17.92 mL
12.5 mM	0.36 mL	1.79 mL	3.58 mL

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References for CGS 19755

References are publications that support the biological activity of the product.

Perez-Pinzon Correlation of CGS 19755 neuroprotection against in vivo excitotoxicity and focal cerebral ischemia. J.Cereb.Blood Flow Metab. 1995 PMID: 7673380
Bennett Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-MthD.-aspartate receptors. J.Pharmacol.Exp.Ther. 1989 PMID: 2547931
Lehmann CGS 19755, a selective and competitive N-MthD.-aspartate-type excitatory amino acid receptor antagonist. J.Pharmacol.Exp.Ther. 1988 PMID: 2899170

Citations for CGS 19755 (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CGS 19755 include:

Richardson and Shelton (2015) N-MthD.-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Cereb Cortex. 352:156
PMID: 25368340
Pan et al. (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. J Pharmacol Exp Ther. 124:4629
PMID: 25202982
Pedrazzi et al. (2012) Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. PLoS One. 7:e44518
PMID: 22952988
Jaekel et al. (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. J Clin Invest. 147:622
PMID: 16314856

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