CGS 12066B dimaleate

Name: CGS 12066B dimaleate
Brand: Tocris Bioscience
SKU: 0638

Tocris Bioscience a Bio-Techne Brand

Catalog # 0638

Citations (3)

COA / SDS

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Key Product Details

Description:	5-HT_1B agonist
Chemical Name:	7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo[1,2-a]-quinoxaline dimaleate
Purity:	≥98% (HPLC)
Molecular Weight:	566.49

View Full Technical Details for CGS 12066B dimaleate

Biological Activity for CGS 12066B dimaleate

CGS 12066B dimaleate is a 5-HT_1B full agonist, 10-fold selective over 5-HT_1A and 1000-fold selective over 5-HT_2C receptors. Centrally active following systemic administration.

Technical Data for CGS 12066B dimaleate

M. Wt	566.49
Formula	C₁₇H₁₇F₃N₄.2C₄H₄O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	109028-10-6
PubChem ID	9915956
InChi Key	HTEVMLYDEWVIQE-SPIKMXEPSA-N
Smiles	O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O.FC(C1=CC3=C(N2C=CC=C2C(N4CCN(CC4)C)=N3)C=C1)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGS 12066B dimaleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.83	5
	DMSO	22.66	40

Preparing Stock Solutions for CGS 12066B dimaleate

The following data is based on the product molecular weight 566.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.4 mM	4.41 mL	22.07 mL	44.13 mL
2 mM	0.88 mL	4.41 mL	8.83 mL
4 mM	0.44 mL	2.21 mL	4.41 mL
20 mM	0.09 mL	0.44 mL	0.88 mL

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References for CGS 12066B dimaleate

References are publications that support the biological activity of the product.

Tomkins and O'Neill Effect of 5-HT_1B receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol.Biochem.Behav. 2000 PMID: 10837852
Schoeffter and Hoyer Interaction of arylpiperazines with 5-HT_1A, 5-HT_1B, 5-HT_1C and 5-HT_1D receptors: do discriminatory 5-HT_1B receptor ligands exist? Naunyn Schmiedebergs Arch.Pharmacol. 1989 PMID: 2770889
Neale Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur.J.Pharmacol. 1987 PMID: 3496228

Citations for CGS 12066B dimaleate (3)

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Citations are publications that use Bio-Techne products. Selected citations for CGS 12066B dimaleate include:

Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmcol. 175
PMID: 32088264
Khatri et al. (2014) Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl). 231:1191
PMID: 23975037
Maciag et al. (2006) Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development. Brain Res. 1125:171
PMID: 17101120

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Product Documents for CGS 12066B dimaleate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.