CGRP 8-37 (human)

Name: CGRP 8-37 (human)
Brand: Tocris Bioscience
SKU: 1181

Catalog # 1181 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

CGRP antagonist

Key Product Details

Description:	CGRP antagonist
Alternative Names:	Calcitonin Gene-Related Peptide 8-37 (human)
Purity:	≥95% (HPLC)
Molecular Weight:	3125.64

View Full Technical Details for CGRP 8-37 (human)

Technical Data
Citations (1) / Reviews

Biological Activity for CGRP 8-37 (human)

CGRP 8-37 (human) is a peptide antagonist for CGRP₁ receptors.

Technical Data for CGRP 8-37 (human)

M. Wt	3125.64
Formula	C₁₃₉H₂₃₀N₄₄O₃₈
Single Letter Sequence	VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF (Modifications: Phe-30 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	119911-68-1
PubChem ID	16134896
InChi Key	NDACAFBDTQIYCQ-YVQXRMNASA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGRP 8-37 (human)

Solubility

Soluble to 0.5mg/ml in water

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References for CGRP 8-37 (human)

References are publications that support the biological activity of the product.

Nakamura Calcitonin gene-related peptide as a GH secretagogue in human and rat pituitary somatotrophs. Brain Res. 1998 PMID: 9757038
Poyner Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br.J.Pharmacol. 1998 PMID: 9756381
Wisskirchen Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br.J.Pharmacol. 1998 PMID: 9605575
Poyner Pharmacology of receptors for calcitonin gene-related peptide and amylin. TiPS 1995 PMID: 8578616

Citations for CGRP 8-37 (human) (1)

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Citations are publications that use Bio-Techne products. Selected citations for CGRP 8-37 (human) include:

Fernandes et al. (2016) Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner. World J Gastroenterol. 18:7
PMID: 26754745

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