CGP 60474

Name: CGP 60474
Brand: Tocris Bioscience
SKU: 5471

Tocris Bioscience, part of Bio-Techne | Catalog # 5471

Citations (4)

COA / SDS

Potent cdk inhibitor

Key Product Details

Description:	Potent cdk inhibitor
Chemical Name:	3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Purity:	≥98% (HPLC)
Molecular Weight:	355.82

View Full Technical Details for CGP 60474

Technical Data
Citations

Biological Activity for CGP 60474

CGP 60474 is a potent cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 3 - 80, 9.5, 13, 17 - 60, 200 and 220 nM for cdk2, cdk5, cdk9, cdk1, cdk4 and cdk7, respectively). Also inhibits PKCα in the low micromolar range. Displays reversible G1/S cell cycle arrest in U2-OS cells.

Technical Data for CGP 60474

M. Wt	355.82
Formula	C₁₈H₁₈ClN₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	164658-13-3
PubChem ID	644215
InChi Key	IYNDTACKOAXKBJ-UHFFFAOYSA-N
Smiles	OCCCNC1=NC=CC(C2=NC(NC3=CC(Cl)=CC=C3)=NC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 60474

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.58	100
	1eq. HCl	17.79	50

Preparing Stock Solutions for CGP 60474

The following data is based on the product molecular weight 355.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.05 mL	28.10 mL
5 mM	0.56 mL	2.81 mL	5.62 mL
10 mM	0.28 mL	1.41 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for CGP 60474

References are publications that support the biological activity of the product.

Sielecki Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. J.Med.Chem. 2000 PMID: 10633033
Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Stanetty Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J.Org.Chem. 2005 PMID: 15960526