CGP 60474
Tocris Bioscience, part of Bio-Techne | Catalog # 5471
Potent cdk inhibitor
Product Description
CGP 60474 is a potent cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 3 - 80, 9.5, 13, 17 - 60, 200 and 220 nM for cdk2, cdk5, cdk9, cdk1, cdk4 and cdk7, respectively). Also inhibits PKCα in the low micromolar range. Displays reversible G1/S cell cycle arrest in U2-OS cells.Product Specifications
Molecular Weight
355.82
Formula
C18H18ClN5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
CAS Number
164658-13-3
PubChem ID
644215
InChI Key
IYNDTACKOAXKBJ-UHFFFAOYSA-N
SMILES
OCCCNC1=NC=CC(C2=NC(NC3=CC(Cl)=CC=C3)=NC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 17.79 | 50 | |
| DMSO | 35.58 | 100 |
Preparing Stock Solutions
for CGP 60474
The following data is based on the product molecular weight 355.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.05 mL | 28.10 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.62 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sielecki Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. J.Med.Chem. 2000 PMID: 10633033
- Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
- Stanetty Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J.Org.Chem. 2005 PMID: 15960526
Product Specific Notices for CGP 60474
For research use only
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