CGP 53353
Tocris Bioscience, part of Bio-Techne | Catalog # 2442
Selective inhibitor of PKCβII
Key Product Details
Description
Selective inhibitor of PKCβII
Product Description
CGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.Product Specifications
Molecular Weight
365.34
Formula
C20H13F2N3O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione
CAS Number
145915-60-2
PubChem ID
6711154
InChI Key
RONQPWQYDRPRGG-UHFFFAOYSA-N
SMILES
FC1=CC=C(NC2=CC3=C(C=C2NC2=CC=C(F)C=C2)C(=O)NC3=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.53 | 100 | |
| Ethanol | 7.31 | 20 |
Preparing Stock Solutions
for CGP 53353
The following data is based on the product molecular weight 365.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.69 mL | 27.37 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA
- Kouroedov Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 2004 PMID: 15210597
Product Specific Notices for CGP 53353
For research use only
Loading...
Loading...