CGP 42112

Name: CGP 42112
Brand: Tocris Bioscience
SKU: 2569

Catalog # 2569 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Selective, high affinity AT2 ligand

Key Product Details

Description:	Selective, high affinity AT₂ ligand
Purity:	≥95% (HPLC)
Molecular Weight:	1052.2

View Full Technical Details for CGP 42112

Technical Data
Citations (3) / Reviews

Biological Activity for CGP 42112

CGP 42112 is a selective, high affinity angiotensin AT₂ receptor ligand (K_i = 0.24 nM). Displays agonistic properties at proximal tubule AT₂ receptors, causes Na⁺, K⁺-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC₅₀ = 1850 nM).

Technical Data for CGP 42112

M. Wt	1052.2
Formula	C₅₂H₆₉N₁₃O₁₁
Single Letter Sequence	YKHPI (Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	127060-75-7
PubChem ID	123794
InChi Key	UXGNARZDONUMMK-LRMQDCNJSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1=CN=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 42112

Solubility

Soluble to 1mg/ml in water

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References for CGP 42112

References are publications that support the biological activity of the product.

Hakam and Hussain Angiotensin II AT₂ receptors inhibit proximal tubular Na⁺-K⁺-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 2006 PMID: 16380464
Naveri The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 1995 PMID: 8610501
Criscione Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol.

Citations for CGP 42112 (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CGP 42112 include:

Raffai et al. (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research. 53:105
PMID: 27676088
Nostramo et al. (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke. 215:291
PMID: 22911895
Li et al. (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer. 43:2483
PMID: 22738920

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