CGP 37157

Name: CGP 37157
Brand: Tocris Bioscience
SKU: 1114

Tocris Bioscience a Bio-Techne Brand

Catalog # 1114

Citations (13)

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Key Product Details

Description:	Antagonist of mitochondrial Na⁺/Ca²⁺ exchange
Chemical Name:	7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Purity:	≥99% (HPLC)
Molecular Weight:	324.22

View Full Technical Details for CGP 37157

Biological Activity for CGP 37157

CGP 37157 is a selective antagonist of the mitochondrial Na⁺-Ca²⁺ exchanger (IC₅₀ = 0.4 μM).

Compound Libraries for CGP 37157

CGP 37157 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 37157

M. Wt	324.22
Formula	C₁₅H₁₁Cl₂NOS
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	75450-34-9
PubChem ID	2688
InChi Key	KQEPIRKXSUIUTH-UHFFFAOYSA-N
Smiles	ClC1=CC=C2NC(=O)CSC(C3=CC=CC=C3Cl)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 37157

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for CGP 37157

The following data is based on the product molecular weight 324.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.42 mL	30.84 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for CGP 37157

References are publications that support the biological activity of the product.

Baron and Thayer CGP37157 modulates mitochondrial Ca²⁺ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 1997 PMID: 9537826
White and Reynolds Mitochondria accumulate Ca²⁺ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 1997 PMID: 9023766
Cox Selectivity of inhibition of Na⁺-Ca²⁺ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 1993 PMID: 7681905
Cox and Matlib Modulation of intramitochondrial free Ca²⁺ concentration by antagonists of Na⁺-Ca²⁺ exchange. TiPS 1993 PMID: 8296399

Citations for CGP 37157 (13)

Showing 1 - 10 of 13 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CGP 37157 include:

Bastioli et al. (2019) Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity. Cell Death Dis. 10:80
PMID: 30692508
Panja et al. (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol. 45:141
PMID: 29679372
Lin et al. (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Elife. 16:5555
PMID: 25768340
Yang et al. (2015) Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. J Biol Chem. 4
PMID: 25974216
Pecze et al. (2015) Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. World J Gastroenterol. 290:28214
PMID: 26396196
Blomeyer et al. (2013) Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr. 45:189
PMID: 23225099
Pandit et al. (2012) Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol. 302:F1325
PMID: 22357920
Zhdanov et al. (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci. 68:903
PMID: 20820851
Midkiff et al. (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One. 6:e25395
PMID: 21966518
Lee et al. (2007) Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. J Neurosci. 27:13603
PMID: 18077672
Kim et al. (2006) Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity. J Biol Chem. 12:796
PMID: 16521198
Nikolaeva et al. (2005) Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia. J Neurosci. 25:9960
PMID: 16251444
Schild et al. (2003) Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration. Am J Physiol Heart Circ Physiol. 278:25454
PMID: 12702720

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