CGP 3466B maleate

Name: CGP 3466B maleate
Brand: Tocris Bioscience
SKU: 2966
Price: 174 USD

Catalog # 2966 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

GAPDH inhibitor; neuroprotective

Key Product Details

Description:	GAPDH inhibitor; neuroprotective
Alternative Names:	TCH 346 maleate
Chemical Name:	N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate
Purity:	≥99% (HPLC)
Molecular Weight:	391.42

View Full Technical Details for CGP 3466B maleate

Biological Activity for CGP 3466B maleate

CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H₂O₂ release. CGP 3466B inhibits colon cancer proliferation in vitro and displays neuroprotective activity in vivo.

Compound Libraries for CGP 3466B maleate

CGP 3466B maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 3466B maleate

M. Wt	391.42
Formula	C₁₉H₁₇NO.C₄H₄O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	200189-97-5
PubChem ID	9821821
InChi Key	SQAZQLMBEHYFJA-BTJKTKAUSA-N
Smiles	O=C(O)/C=C\C(O)=O.CN(CC#C)CC2=CC1=CC=CC=C1OC3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 3466B maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.91	10
	DMSO	39.14	100

Preparing Stock Solutions for CGP 3466B maleate

The following data is based on the product molecular weight 391.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.77 mL	25.55 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for CGP 3466B maleate

References are publications that support the biological activity of the product.

Bazzocco Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment. Clin.Cancer Res. 2015 PMID: 25944804
Zoccarato Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H₂O₂ release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr. 2008 PMID: 18763029
Andringa TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis. 2003 PMID: 14572443
Sagot An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol. 2000 PMID: 11030721

Citations for CGP 3466B maleate (1)

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Citations are publications that use Bio-Techne products. Selected citations for CGP 3466B maleate include:

Xu et al. (2013) Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling. Neuron. 78:623
PMID: 23719162

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