CGP 20712 dihydrochloride
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | Highly potent and selective β1 antagonist |
Chemical Name: | 1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride |
Purity: | ≥96% (HPLC) |
Molecular Weight: | 567.39 |
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Citations for CGP 20712 dihydrochloride (16)
Citations are publications that use Bio-Techne products. Selected citations for CGP 20712 dihydrochloride include:
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Lavine
(2017)
β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
Invest Ophthalmol Vis Sci.
58(1):299
PMID: 28114591 -
Ardestani et al.
(2017)
Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist.
Neuropharmacology.
116:371
PMID: 28089846 -
Creed et al.
(2015)
β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
Breast Cancer Res.
17:145
PMID: 26607426 -
Littmann et al.
(2015)
Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
J Biol Chem.
355:183
PMID: 26306764 -
Weiterer et al.
(2015)
Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium.
J Neurochem.
10:e0143163
PMID: 26571499 -
Gherbi et al.
(2014)
Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP.
Br J Pharmacol.
171:5431
PMID: 25052258 -
Lavine et al.
(2013)
Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
JAMA Ophthalmol.
131:376
PMID: 23303344 -
Mistry et al.
(2013)
Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.
J Med Chem.
56:3852
PMID: 23614528 -
Cheng et al.
(2012)
Cytoskeletal role in protection of the failing heart by β-adrenergic blockade.
Am J Physiol Heart Circ Physiol.
302:H675
PMID: 22081703 -
Rieg et al.
(2012)
Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
PLoS One.
6:e29698
PMID: 22216346 -
Hott et al.
(2012)
Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
Br J Pharmacol.
167:207
PMID: 22506532 -
Rankovic et al.
(2011)
Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
PLoS One.
6:e27474
PMID: 22164209 -
Sucharov et al.
(2011)
β-Adrenergic receptor stimulation and activation of protein kinase A protect against α1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5.
Circulation.
17:592
PMID: 21703532 -
Crestani et al.
(2008)
Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats.
Br J Pharmacol.
153:583
PMID: 18037912 -
Lemke et al.
(2008)
Unchanged β-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice.
PLoS One.
283:34738
PMID: 18829456 -
Jane-Wit et al.
(2007)
β 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis.
J Pharmacol Exp Ther.
116:399
PMID: 17620508
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