CGK 733

Tocris Bioscience, part of Bio-Techne | Catalog # 2639

Induces apoptosis in prematurely senescent cells
Discontinued Product
2639 has been discontinued. View all ATM and ATR Kinase Inhibitors products.

Key Product Details

Description

Induces apoptosis in prematurely senescent cells

View all ATM and ATR Kinase Inhibitors »

Product Description

Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.

Product Specifications

Molecular Weight

555.84

Formula

C23H18Cl3FN4O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide

CAS Number

905973-89-9

PubChem ID

6605258

InChI Key

HLCDNLNLQNYZTK-UHFFFAOYSA-N

SMILES

[O-][N+](=O)C1=CC(NC(=S)NC(NC(=O)C(C2=CC=CC=C2)C2=CC=CC=C2)C(Cl)(Cl)Cl)=CC=C1F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.58 100

Preparing Stock Solutions for CGK 733

The following data is based on the product molecular weight 555.84

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.80 mL 9.00 mL 17.99 mL
5 mM 0.36 mL 1.80 mL 3.60 mL
10 mM 0.18 mL 0.90 mL 1.80 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CGK 733

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGK 733

For research use only

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