Cetrorelix acetate
Tocris Bioscience, part of Bio-Techne | Catalog # 8821
Potent GnRH receptor antagonist
Product Description
Cetrorelix acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM). Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Also exhibits anxiolytic and antidepressant activity in vivo.Product Specifications
Molecular Weight
1431.06
Formula
C70H92ClN17O14
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
145672-81-7
PubChem ID
25074887
InChI Key
SBNPWPIBESPSIF-MHWMIDJBSA-N
SMILES
CC(C[C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](C(N)=O)C)=O)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)CO)=O)CC6=CC=C(C=C6)O)=O)CCCNC(N)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in 0.02 M acetic acid |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gründker and Emons Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod.Biol.Endocrinol. 2003 PMID: 14594454
- Telegdy Effects of the LHRH antagonist cetro. on the brain function in mice. Neuropeptides 2009 PMID: 19375162
- Beckers Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal.Biochem. 1997 PMID: 9300077
Product Specific Notices for Cetrorelix acetate
For research use only
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