Cerestat
Tocris Bioscience, part of Bio-Techne | Catalog # 4492
Potent and noncompetitive NMDA antagonist
Key Product Details
Description
Potent and noncompetitive NMDA antagonist
Alternative Names
CNS 1102
Product Description
Cerestat is a potent and noncompetitive NMDA receptor antagonist (IC50 = 36 nM). Exhibits >70-fold selectivity for NMDA receptor over σ receptor. Neuroprotective in a rat model of focal ischemia.Product Specifications
Molecular Weight
339.86
Formula
C20H21N3.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine hydrochloride
CAS Number
137160-11-3
PubChem ID
60839
InChI Key
CKAKVKWRMCAYJD-UHFFFAOYSA-N
SMILES
N=C(N(C)C3=CC=CC(CC)=C3)NC1=C2C(C=CC=C2)=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 16.99 | 50 | |
| DMSO | 33.99 | 100 |
Preparing Stock Solutions
for Cerestat
The following data is based on the product molecular weight 339.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.71 mL | 29.42 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schäbitz The N-MthD.-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 2000 PMID: 10884477
- Reddy Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist. J.Med.Chem. 1994 PMID: 8295213
Product Specific Notices for Cerestat
For research use only
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