Ceramide

Name: Ceramide
Brand: Tocris Bioscience
SKU: 0744

Catalog # 0744

Citations (1)

COA / SDS

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Key Product Details

Description:	Ser/Thr protein phosphatase activator
Chemical Name:	N-Acetylsphingosine
Molecular Weight:	341.53

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Biological Activity

Ceramide is a potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.

Compound Libraries

Ceramide is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	341.53
Formula	C₂₀H₃₉NO₃
Storage	Desiccate at -20°C
CAS Number	3102-57-6
PubChem ID	5497136
InChi Key	BLTCBVOJNNKFKC-QUDYQQOWSA-N
Smiles	OC[C@@](NC(C)=O)([H])[C@H](O)/C([H])=C([H])/CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	34.15	100
	DMSO	34.15	100

Preparing Stock Solutions

The following data is based on the product molecular weight 341.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.64 mL	29.28 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.46 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Molarity Calculator

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Xie and Johnson Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. J.Neurochem. 1997 PMID: 9282924
Quintans Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem.Biophys.Res.Commun. 1994 PMID: 8048941
Dobowsky and Hannun Ceramide stimulates a cytosolic protein phosphatase. J.Biol.Chem. 1992 PMID: 1312082
Kim Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-IF.. J.Biol.Chem. 1991 PMID: 1845977

Citations for Ceramide (1)

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Citations are publications that use Bio-Techne products. Selected citations for Ceramide include:

Samokhvalov et al. (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Pharmacol Biochem Behav. 232:44105
PMID: 25300478

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