Centrinone B
Tocris Bioscience, part of Bio-Techne | Catalog # 5690
High affinity and selective PLK4 inhibitor
Key Product Details
Description
High affinity and selective PLK4 inhibitor
Alternative Names
LCR 323
Product Description
Centrinone B is a high affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.Licensing Information
Sold with the permission of the Ludwig Institute for Cancer Research LtdProduct Specifications
Molecular Weight
631.67
Formula
C27H27F2N7O5S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
CAS Number
1798871-31-4
PubChem ID
118704753
InChI Key
UPZNTUYHCRQOIQ-UHFFFAOYSA-N
SMILES
FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCCCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.58 | 50 |
Preparing Stock Solutions
for Centrinone B
The following data is based on the product molecular weight 631.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.17 mL | 15.83 mL | 31.66 mL |
| 2.5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
| 5 mM | 0.32 mL | 1.58 mL | 3.17 mL |
| 25 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wong Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 2015 PMID: 25931445
Product Specific Notices for Centrinone B
For research use only
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