Ceapin A7
Tocris Bioscience, part of Bio-Techne | Catalog # 6955
Selective inhibitor of ATF6α; sensitizes cells to ER stress
Key Product Details
Description
Selective inhibitor of ATF6α; sensitizes cells to ER stress
Product Description
Ceapin A7 is a selective inhibitor of ATF6α (IC50=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.Product Specifications
Molecular Weight
470.33
Formula
C20H12F6N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[1-[[2,4-bis(Trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-3-isoxazolecarboxamide
CAS Number
2323027-38-7
PubChem ID
154730128
InChI Key
UJTDYOXTXGBHEG-UHFFFAOYSA-N
SMILES
FC(F)(C1=CC(C(F)(F)F)=C(C=C1)CN2C=C(C=N2)NC(C3=NOC(C4=CC=CO4)=C3)=O)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.03 | 100 | |
| Ethanol | 4.7 | 10 |
Preparing Stock Solutions
for Ceapin A7
The following data is based on the product molecular weight 470.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.63 mL | 21.26 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gallagher and Walter Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. eLife 2016 PMID: 27435962
- Gallagher Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. eLife 2016 PMID: 27435960
Product Specific Notices for Ceapin A7
For research use only
Loading...
Loading...