CDPPB

Name: CDPPB
Brand: Tocris Bioscience
SKU: 3235

Tocris Bioscience a Bio-Techne Brand

Catalog # 3235

Citations (5)

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Key Product Details

Description:	Positive allosteric modulator of mGlu₅ receptors
Chemical Name:	3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	364.4

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Biological Activity for CDPPB

CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu₅ receptor (EC₅₀ values are 10 and 20 nM for human and rat receptors respectively). Antipsychotic; reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Compound Libraries for CDPPB

CDPPB is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CDPPB

M. Wt	364.4
Formula	C₂₃H₁₆N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	781652-57-1
PubChem ID	11245456
InChi Key	BKUIZWILNWHFHD-UHFFFAOYSA-N
Smiles	O=C(C4=CC(C#N)=CC=C4)NC1=CC(C3=CC=CC=C3)=NN1C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CDPPB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	27.33	75

Preparing Stock Solutions for CDPPB

The following data is based on the product molecular weight 364.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.66 mL	18.29 mL	36.59 mL
3.75 mM	0.73 mL	3.66 mL	7.32 mL
7.5 mM	0.37 mL	1.83 mL	3.66 mL
37.5 mM	0.07 mL	0.37 mL	0.73 mL

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References for CDPPB

References are publications that support the biological activity of the product.

Chen Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol.Pharmacol. 2007 PMID: 17303702
Kinney A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rats behavioral models. J.Pharmacol.Exp.Ther. 2005 PMID: 15608073
Lindsley Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J.Med.Chem. 2004 PMID: 15537338

Citations for CDPPB (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for CDPPB include:

Bellozi et al. (2019) A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mice models of Alzheimer's disease. Neuropharmacology.. 160:107785
PMID: 31541651
Vicidomini et al. (2017) Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry. 22:689
PMID: 27021819
Martinez et al. (2016) OE Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5. Eneuro. 3
PMID: 27822496
Arsenault et al. (2015) Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS One. 10:e0142093
PMID: 26536027
Pacey et al. (2011) Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. Front Pharmacol. 338:897
PMID: 21636656

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