CD38 inhibitor 78c

Product Description

CD38 inhibitor 78c is a potent CD38 (ADP ribosyl cyclase/hydrolase) inhibitor (IC₅₀ values are 1.9 and 7.3 nM at mouse and human CD38, respectively). Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate. Elevates NAD⁺ levels >5-fold in liver and >1.2-fold in muscle of diet-induced obese (DIO) C57Bl6 mice. Also prevents age-related NAD⁺ decline in mice. Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice.

Solubility

Preparing Stock Solutions for CD38 inhibitor 78c

The following data is based on the product molecular weight 413.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Haffner Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors. J.Med.Chem. 2015 PMID: 25828863
• Tarrago A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD⁺ decline. Cell Metab. 2018 PMID: 29719225