CD 2665
Tocris Bioscience, part of Bio-Techne | Catalog # 3800
Selective RARβ/γ antagonist
Key Product Details
Description
Selective RARβ/γ antagonist
Product Description
CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.Product Specifications
Molecular Weight
486.60
Formula
C31H34O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
CAS Number
170355-78-9
PubChem ID
216241
InChI Key
JBALRFFXKQPVLT-UHFFFAOYSA-N
SMILES
COCCOCOC(C(C3(CC5C4)CC(C5)CC4C3)=C2)=CC1=C2C=C(C6=CC=C(C(O)=O)C=C6)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.66 | 100 |
Preparing Stock Solutions
for CD 2665
The following data is based on the product molecular weight 486.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.28 mL | 20.55 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.11 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meister Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 1998 PMID: 9673404
- Kim The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 2000 PMID: 10651997
- Szondy Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 1997 PMID: 9187263
Product Specific Notices for CD 2665
For research use only
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