CD 2665

Name: CD 2665
Brand: Tocris Bioscience
SKU: 3800

Catalog # 3800 | Tocris Bioscience a Bio-Techne Brand

Citations (10)

COA / SDS

Selective RARβ/γ antagonist

Key Product Details

Description:	Selective RARβ/γ antagonist
Chemical Name:	4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	486.6

View Full Technical Details for CD 2665

Technical Data
Citations (10) / Reviews

Biological Activity for CD 2665

CD 2665 is a selective RARβγ antagonist (K_D values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Blocks retinoic acid-induced apoptosis ex vivo.

Compound Libraries for CD 2665

CD 2665 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CD 2665

M. Wt	486.6
Formula	C₃₁H₃₄O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	170355-78-9
PubChem ID	216241
InChi Key	JBALRFFXKQPVLT-UHFFFAOYSA-N
Smiles	COCCOCOC(C(C3(CC5C4)CC(C5)CC4C3)=C2)=CC1=C2C=C(C6=CC=C(C(O)=O)C=C6)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD 2665

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.66	100

Preparing Stock Solutions for CD 2665

The following data is based on the product molecular weight 486.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.28 mL	20.55 mL
5 mM	0.41 mL	2.06 mL	4.11 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CD 2665

References are publications that support the biological activity of the product.

Kim The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 2000 PMID: 10651997
Meister Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 1998 PMID: 9673404
Szondy Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 1997 PMID: 9187263

Citations for CD 2665 (10)

Showing 1 - 10 of 10 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for CD 2665 include:

Mei et al. (2023) IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis. Front Immunol. 14:1151468
PMID: 37180157
Ane et al. (2021) Retinoic acid signaling is critical during the totipotency window in early mammalian development. Nat Struct Mol Biol. 28:521-532
PMID: 34045724
David A et al. (2019) Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells. Hepatology. 69:785-802
PMID: 30055117
Uchibe et al. (2017) Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. J Orthop Res. 35:1096
PMID: 27325507
Chronopoulos et al. (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications. 7:12630
PMID: 27600527
Centritto et al. (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. Mucosal Immunol. 7:950
PMID: 25888236
Martin et al. (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol. 7:101
PMID: 23653115
Simkin et al. (2013) Retinoic acid upregulates ret and induces chain migration and population expansion in vagal neural crest cells to colonise the embryonic gut. PLoS One. 8:e64077
PMID: 23717535
Liang et al. (2013) Retinoic acid inhibits CD25+ dendritic cell expansion and γδ T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 54:3493
PMID: 23611991
Kang et al. (2011) Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Autophagy. 4:66
PMID: 20664575

There are no citations that match your criteria.