CCT 369260
Tocris Bioscience, part of Bio-Techne | Catalog # 7799
Molecular glue; induces degradation of BCL6
Key Product Details
Description
Molecular glue; induces degradation of BCL6
Product Description
CCT 369260 acts as a potent BCL6 molecular glue Degrader (IC50 = 54 nM). It reduces BCL6 levels in a lymphoma xenograft mouse model. CCT 369260 is orally bioavailable.Product Specifications
Molecular Weight
509.00
Formula
C24H31ClF2N6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one
CAS Number
2253878-44-1
PubChem ID
135386938
InChI Key
VFNPUAOAEFMXQI-GASCZTMLSA-N
SMILES
CC(C)(O)CCN1C2=CC(NC3=NC(N4C[C@@H](C(F)([C@@H](C4)C)F)C)=NC=C3Cl)=CC=C2N(C1=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.45 | 50 |
Preparing Stock Solutions
for CCT 369260
The following data is based on the product molecular weight 509.00
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.93 mL | 19.65 mL | 39.29 mL |
| 2.5 mM | 0.79 mL | 3.93 mL | 7.86 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.79 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bellenie Achieving in vivo target depletion through the discovery and optimization of Benzimidazolone BCL6 degraders. J.Med.Chem. 2020 PMID: 32275432
Product Specific Notices for CCT 369260
For research use only
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