CCMI

Tocris Bioscience, part of Bio-Techne | Catalog # 3837

Positive allosteric modulator of α7 nAChRs
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Key Product Details

Description

Positive allosteric modulator of α7 nAChRs

Alternative Names

XY 4083

View all Nicotinic (a7) Receptor Modulators »

Product Description

CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons.

Product Specifications

Molecular Weight

388.25

Formula

C19H15Cl2N3O2

Storage

Store at -20°C

Chemical Name

[N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide

CAS Number

917837-54-8

PubChem ID

67042344

InChI Key

VMAKIACTLSBBIY-UHFFFAOYSA-N

SMILES

CC1=NOC(=C1)C(=CNC1=CC=C(Cl)C=C1)C(=O)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.83 100
Ethanol 3.88 10

Preparing Stock Solutions for CCMI

The following data is based on the product molecular weight 388.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.88 mL 25.76 mL
5 mM 0.52 mL 2.58 mL 5.15 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CCMI

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CCMI

For research use only

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