CBM 301940

Name: CBM 301940
Brand: Tocris Bioscience
SKU: 6319

Tocris Bioscience, part of Bio-Techne | Catalog # 6319

Citations (1)

COA / SDS

Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable

Key Product Details

Description:	Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Chemical Name:	tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
Purity:	≥98% (HPLC)
Molecular Weight:	422.32

View Full Technical Details for CBM 301940

Technical Data
Citations

Biological Activity for CBM 301940

CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor (IC₅₀ = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.

Compound Libraries for CBM 301940

CBM 301940 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CBM 301940

M. Wt	422.32
Formula	C₁₅H₂₀F₆N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	902146-11-6
PubChem ID	10387489
InChi Key	SBPVPWWNQIKSKL-UHFFFAOYSA-N
Smiles	CC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CBM 301940

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	42.23	100
	ethanol	42.23	100

Preparing Stock Solutions for CBM 301940

The following data is based on the product molecular weight 422.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.68 mL
5 mM	0.47 mL	2.37 mL	4.74 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for CBM 301940

References are publications that support the biological activity of the product.

Cheng Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 2006 PMID: 16821767
Dyck Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 2004 PMID: 15105298