CBM 301940
Tocris Bioscience, part of Bio-Techne | Catalog # 6319
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Key Product Details
Description
Potent malonyl-CoA decarboxylase inhibitor; orally bioavailable
Product Description
CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor (IC50 = 23 nM). Suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Improves cardiac function during reperfusion of ischemic isolated rat hearts. Orally bioavailable.Product Specifications
Molecular Weight
422.32
Formula
C15H20F6N2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate
CAS Number
902146-11-6
PubChem ID
10387489
InChI Key
SBPVPWWNQIKSKL-UHFFFAOYSA-N
SMILES
CC(NC(C1=NOC(C(C(F)(F)F)(C(F)(F)F)O)C1)=O)CC(OC(C)(C)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.23 | 100 | |
| Ethanol | 42.23 | 100 |
Preparing Stock Solutions
for CBM 301940
The following data is based on the product molecular weight 422.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.68 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheng Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J.Med.Chem. 2006 PMID: 16821767
- Dyck Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ.Res. 2004 PMID: 15105298
Product Specific Notices for CBM 301940
For research use only
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