CBA
Tocris Bioscience, part of Bio-Techne | Catalog # 6724
Selective TRPM4 blocker
Product Description
CBA is a selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro.Product Specifications
Molecular Weight
340.16
Formula
C15H11Cl2NO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
CAS Number
351424-20-9
PubChem ID
2264067
InChI Key
CVQCJPCMPGKEDH-UHFFFAOYSA-N
SMILES
OC(C1=C(C=C(C=C1)Cl)NC(COC2=C(C=CC=C2)Cl)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.01 | 50 |
Preparing Stock Solutions
for CBA
The following data is based on the product molecular weight 340.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.88 mL | 29.40 mL | 58.80 mL |
| 2.5 mM | 1.18 mL | 5.88 mL | 11.76 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.88 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ozhathil Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 2018 PMID: 29579323
- Bianchi The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 2018 PMID: 29996905
Product Specific Notices for CBA
For research use only
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