CB 65

Tocris Bioscience, part of Bio-Techne | Catalog # 2663

COA / SDS

High affinity, selective CB2 agonist

Key Product Details

Description:	High affinity, selective CB₂ agonist
Chemical Name:	N-Cyclohexyl-7-chloro-1-[2-(4-morpholinyl)ethyl]quinolin-4(1H)-one-3-carboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	417.93

View Full Technical Details for CB 65

Technical Data
Citations

Biological Activity for CB 65

CB 65 is a high affinity and selective CB₂ receptor agonist; K_i values are 3.3 and > 1000 nM for CB₂ and CB₁ receptors respectively.

Technical Data for CB 65

M. Wt	417.93
Formula	C₂₂H₂₈ClN₃O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	913534-05-1
PubChem ID	16086891
InChi Key	MFKWLGOHFQBVAA-UHFFFAOYSA-N
Smiles	ClC1=CC=C2C(N(CCN3CCOCC3)C=C(C(NC4CCCCC4)=O)C2=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CB 65

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.09	5 with gentle warming

Preparing Stock Solutions for CB 65

The following data is based on the product molecular weight 417.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	47.85 mL	239.27 mL	478.55 mL
0.25 mM	9.57 mL	47.85 mL	95.71 mL
0.5 mM	4.79 mL	23.93 mL	47.85 mL
2.5 mM	0.96 mL	4.79 mL	9.57 mL

Molarity Calculator

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Reconstitution Calculator

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References for CB 65

References are publications that support the biological activity of the product.

Manera Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB₂ selective agonists. J.Med.Chem. 2006 PMID: 17004710