CB 5083

Tocris Bioscience, part of Bio-Techne | Catalog # 7379

Potent p97 ATPase inhibitor
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Key Product Details

Description

Potent p97 ATPase inhibitor

View all p97 ATPase Inhibitors »

Product Description

CB 5083 is a potent p97 inhibitor, inhibiting the D2 ATPase domain (IC50 = 11 nM). CB 5083 shows broad antitumor activity and inhibits tumor growth in vivo. CB 5083 is cytotoxic to A549 cancer cells (IC50 = 680 nM) and reduces cell viablility in a range of colorectal cancer cell lines. Increases CHOP and GRP78 protein levels, upregulates PD-L1 mRNA levels and results in the loss of aggresomes.

Product Specifications

Molecular Weight

413.48

Formula

C24H23N5O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[7,8-Dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide

CAS Number

1542705-92-9

PubChem ID

73051434

InChI Key

RDALZZCKQFLGJP-UHFFFAOYSA-N

SMILES

O=C(N)C1=CC=CC2=C1C=C(N2C=3N=C(NCC=4C=CC=CC4)C5=C(N3)CCOC5)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.35 100
Ethanol 41.35 100

Preparing Stock Solutions for CB 5083

The following data is based on the product molecular weight 413.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CB 5083

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CB 5083

For research use only

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