Catestatin

Name: Catestatin
Brand: Tocris Bioscience
SKU: 2722

Tocris Bioscience a Bio-Techne Brand

Catalog # 2722

COA / SDS

Discontinued Product

2722 has been discontinued. View all Additional Nicotinic Receptor Antagonists products.

Key Product Details

Description:	Non-competitive nAChR antagonist
Alternative Names:	Chromogranin A_344-364
Molecular Weight:	2425.84

View Full Technical Details for Catestatin

Biological Activity for Catestatin

Catestatin is a non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC₅₀ ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC₅₀ ~ 200 - 250 nM) and inhibits nicotinic-agonist induced desensitization of catecholamine release. Also stimulates mast cell release of histamine via a separate mechanism.

Technical Data for Catestatin

M. Wt	2425.84
Formula	C₁₀₇H₁₇₃N₃₇O₂₆S
Single Letter Sequence	RSMRLSFRARGYGFRGPGLQL
Storage	Store at -20°C
CAS Number	142211-96-9
PubChem ID	16143960
InChi Key	HCEYIDADOJWYIM-DIWOTYQXSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Catestatin

Solubility

Soluble to 1mg/ml in water

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References for Catestatin

References are publications that support the biological activity of the product.

Kruger Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides. Regul.Peptides
Mahata Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A344-364): identification of amino acid residues crucial for activity. Mol.Endocrinol. 2000 PMID: 11043569
Mahata Novel autocrine feedback control of catecholamine release. J.Clin.Invest. 1997 PMID: 9294131

Citations for Catestatin

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