Caspase-9 Inhibitor Z-LEHD-FMK
R&D Systems, part of Bio-Techne | Catalog # FMK008
Key Product Details
Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
Conjugate
Unconjugated
Formulation, Preparation and Storage
FMK008
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. |
Background: Caspase-9
Caspase-9, also known as APAF-3, Mch6 and ICE-LAP6, is a 35-37 kDa member of the peptidase C14A family of enzymes. Caspase-9 is an initiator caspase that is part of the intrinsic apoptosis pathway. It is widely expressed and is particularly important during development. Following mitochondrial disruption, Cytochrome c is released from mitochrondria and interacts with APAF-1, resulting in Pro-Caspase-9 dimerization. The act of dimerization activates Pro-Caspase-9, leading to its autocleavage into p35 and p12 subunits or to its activation of Caspase-3. Activated Caspase-3 can also act on Pro-Caspase-9, generating a 37 kDa subunit and a 10 kDa subunit.
Additional Caspase-9 Products
Product Documents for Caspase-9 Inhibitor Z-LEHD-FMK
Product Specific Notices for Caspase-9 Inhibitor Z-LEHD-FMK
For research use only
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