Capzimin dimer

Name: Capzimin dimer
Brand: Tocris Bioscience
SKU: 6781

Tocris Bioscience a Bio-Techne Brand

Catalog # 6781

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Key Product Details

Description:	Selective proteasome inhibitor
Chemical Name:	8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Purity:	≥98% (HPLC)
Molecular Weight:	628.8

View Full Technical Details for Capzimin dimer

Biological Activity for Capzimin dimer

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC₅₀ = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC₅₀ = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.

Technical Data for Capzimin dimer

M. Wt	628.8
Formula	C₃₀H₂₄N₆O₂S₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2084868-04-0
PubChem ID	126599606
InChi Key	RNEOHKZPZKEZCQ-UHFFFAOYSA-N
Smiles	O=C(C1=CC2=C(C(SSC3=CC=CC4=C3N=CC(C(NCCC5=NC=CS5)=O)=C4)=CC=C2)N=C1)NCCC6=NC=CS6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Capzimin dimer

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	62.88	100

Preparing Stock Solutions for Capzimin dimer

The following data is based on the product molecular weight 628.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.95 mL	15.90 mL
5 mM	0.32 mL	1.59 mL	3.18 mL
10 mM	0.16 mL	0.80 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for Capzimin dimer

References are publications that support the biological activity of the product.

Perez Discovery of an inhibitor of the proteasome subunit Rpn11. J.Med.Chem. 2017 PMID: 28191850
Li Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat.Chem.Biol. 2017 PMID: 28244987

Citations for Capzimin dimer

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