Key Product Details
Description: | TRPV antagonist; also activator of ENaCδ |
Chemical Name: | N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 376.9 |
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Citations for Capsazepine (55)
Citations are publications that use Bio-Techne products. Selected citations for Capsazepine include:
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Diniz et al.
(2019)
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
PeerJ.
7:e6493
PMID: 30809460 -
Cheng et al.
(2019)
The role of Nav1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes.
Theranostics.
9:4287
PMID: 31285762 -
Balleza-Tapia et al.
(2018)
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.
Elife.
7
PMID: 30417826 -
Kamiya et al.
(2018)
Electrophysiological measurement of ion channels on plasma/organelle membranes using an on-chip lipid bilayer system.
Sci Rep.
8:17498
PMID: 30504856 -
Saliba
(2017)
AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity.
J Neuroinflammation.
14(1):246
PMID: 29237478 -
Wu and Tasker
(2017)
Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells following Chronic Dehydration.
Eneuro.
4
PMID: 28966975 -
Ma et al.
(2015)
Experimental evidence for alleviating nociceptive hypersensitivity by single application of capsaicin.
Mol Pain.
11:22
PMID: 25896608 -
Wang et al.
(2015)
Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice.
Int J Mol Sci.
5:16768
PMID: 26602811 -
Lin et al.
(2015)
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
J Neurosci.
16:5555
PMID: 25768340 -
Eskander et al.
(2015)
Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.
Br J Pharmacol.
35:8593
PMID: 26041925 -
Borrelli et al.
(2015)
Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent.
PLoS One.
172:142
PMID: 25205418 -
Smith et al.
(2015)
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
PLoS One.
10:e0136546
PMID: 26414859 -
Vijayvergiya et al.
(2015)
Measurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.
PLoS One.
10:e0141366
PMID: 26513481 -
Rossi et al.
(2014)
Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53.
Mol Neurodegener.
9:56
PMID: 25495224 -
Wang et al.
(2014)
Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
Am J Physiol Gastrointest Liver Physiol.
307:G719
PMID: 25147231 -
Nguyen et al.
(2014)
Transient receptor potential vanilloid type 1 channel may modulate opioid reward.
Neuropsychopharmacology.
39:2414
PMID: 24732880 -
Morelli et al.
(2014)
Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
BMC Cancer.
14:921
PMID: 25481381 -
Lu et al.
(2014)
H2 S modulates duodenal motility in male rats via activating TRPV1 and K(ATP) channels.
Proc Natl Acad Sci U S A.
171:1534
PMID: 24345161 -
Graham et al.
(2013)
Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1.
J Cell Sci.
126:4602
PMID: 23943873 -
Malenczyk et al.
(2013)
CB1 cannabinoid receptors couple to focal adhesion kinase to control Ins release.
J Biol Chem.
288:32685
PMID: 24089517 -
Derbenev and Smith
(2013)
Dexamethasone rapidly increases GABA release in the dorsal motor nucleus of the vagus via retrograde messenger-mediated enhancement of TRPV1 activity.
PLoS One.
8:e70505
PMID: 23936221 -
Liu et al.
(2012)
Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Mol Cancer Ther.
11:1421
PMID: 22553354 -
Albert et al.
(2012)
TRPV4 channels mediate the infrared laser-evoked response in sensory neurons.
J Neurophysiol.
107:3227
PMID: 22442563 -
Casarotto et al.
(2012)
Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Br J Pharmacol.
37:478
PMID: 21937980 -
Kaszás et al.
(2012)
Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
Dev Neurosci.
340:152
PMID: 22005042 -
Muzzi et al.
(2012)
Ischemic neuroprotection by TRPV1 receptor-induced hypothermia.
Br J Pharmacol.
32:978
PMID: 22434066 -
Ruparel et al.
(2012)
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
Mol Pain.
8:73
PMID: 23006841 -
Hamtiaux et al.
(2012)
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
BMC Cancer.
12:92
PMID: 22429826 -
Li and Burrell
(2011)
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Learn Mem.
18:545
PMID: 21844187 -
Canetta et al.
(2011)
Type III Nrg1 back signaling enhances functional TRPV1 along sensory axons contributing to basal and inflammatory thermal pain sensation.
J Cereb Blood Flow Metab.
6:e25108
PMID: 21949864 -
Ruparel et al.
(2011)
Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine.
Neurochem Int.
80:117
PMID: 21441412 -
Samineni et al.
(2011)
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray.
Brain Res.
1389:177
PMID: 21439272 -
Hamtiaux et al.
(2011)
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism.
PLoS One.
6:e26823
PMID: 22046372 -
Yuan and Burrell
(2010)
Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
J Neurophysiol.
104:2766
PMID: 20884761 -
Kim and Alger
(2010)
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Nat Neurosci.
13:592
PMID: 20348918 -
Buznikov et al.
(2010)
A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
Exp Neurol.
32:43101
PMID: 19907129 -
Bhaskaran and Smith
(2010)
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Br J Pharmacol.
223:529
PMID: 20144892 -
Gibson et al.
(2008)
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Neuron.
57:746
PMID: 18341994 -
Melis et al.
(2008)
Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors.
J Neurosci.
28:13985
PMID: 19091987 -
Benninger et al.
(2008)
Control of excitatory synaptic transmission by capsaicin is unaltered in TRPV1 vanilloid receptor knockout mice.
J Pharmacol Exp Ther.
52:89
PMID: 17651868 -
Bambico et al.
(2007)
Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex.
J Neurosci.
27:11700
PMID: 17959812 -
Akerman et al.
(2007)
Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons.
J Pharmacol Exp Ther.
320:64
PMID: 17018694 -
Moezi et al.
(2006)
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
J Pharmacol Exp Ther.
149:898
PMID: 17043671 -
Gavva et al.
(2005)
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
J Pharmacol Exp Ther.
313:474
PMID: 15615864 -
Kwolek et al.
(2005)
Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats.
Br J Pharmacol.
145:567
PMID: 15834445 -
Bautista et al.
(2005)
Pungent products from garlic activate the sensory ion channel TRPA1.
Br J Pharmacol.
102:12248
PMID: 16103371 -
Akerman et al.
(2004)
Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors.
Br J Pharmacol.
142:1354
PMID: 15277315 -
Price et al.
(2004)
Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
Br J Pharmacol.
142:257
PMID: 15155534 -
Baker
(2004)
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.
Br J Pharmacol.
142:1361
PMID: 15277316 -
Melis et al.
(2004)
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors.
J Neurosci.
24:53
PMID: 14715937 -
Akerman et al.
(2003)
Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation.
Sci Rep.
140:718
PMID: 14534154 -
Mazzone and Canning
(2002)
Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs.
Am J Physiol Regul Integr Comp Physiol.
283:R86
PMID: 12069934 -
Kagaya et al.
(2002)
Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve.
Br J Pharmacol.
137:39
PMID: 12183329 -
Craib et al.
(2001)
A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.
Mol Pharmacol.
134:42581
PMID: 11522594 -
Izzo et al.
(2001)
Effect of vanilloid drugs on gastrointestinal transit in mice.
Br J Pharmacol.
132:1411
PMID: 11264233
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