Canertinib dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5916
Potent EGFR kinase inhibitor
Key Product Details
Description
Potent EGFR kinase inhibitor
Alternative Names
CI 1033,PD 183805
Product Description
Canertinib dihydrochloride is a potent EGFR kinase inhibitor (IC50 = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
558.86
Formula
C24H25ClFN5O3.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride
CAS Number
289499-45-2
PubChem ID
156413
InChI Key
JZZFDCXSFTVOJY-UHFFFAOYSA-N
SMILES
O=C(C=C)NC1=C(OCCCN4CCOCC4)C=C(N=CN=C2NC3=CC(Cl)=C(F)C=C3)C2=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 11.18 | 20 | |
| DMSO | 55.89 | 100 |
Preparing Stock Solutions
for Canertinib dihydrochloride
The following data is based on the product molecular weight 558.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.79 mL | 8.95 mL | 17.89 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.79 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for Canertinib dihydrochloride
For research use only
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