Camostat mesylate

Name: Camostat mesylate
Brand: Tocris Bioscience
SKU: 3193
Rating: 3 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3193

Citations (7)

(1)

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Key Product Details

Description:	Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells
Chemical Name:	4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	494.52

View Full Technical Details for Camostat mesylate

Biological Activity for Camostat mesylate

Camostat mesylate is an orally active protease inhibitor. Inhibits trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration. Also inhibits transmembrane serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (COVID-19) into lung cells in vitro.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Camostat mesylate

Camostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Camostat mesylate

M. Wt	494.52
Formula	C₂₀H₂₂N₄O₅.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	59721-29-8
PubChem ID	43071
InChi Key	FSEKIHNIDBATFG-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Camostat mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.73	50
	DMSO	49.45	100

Preparing Stock Solutions for Camostat mesylate

The following data is based on the product molecular weight 494.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.11 mL	20.22 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for Camostat mesylate

References are publications that support the biological activity of the product.

Hoffmann SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 2020 PMID: 32142651
Ishikura The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 2007 PMID: 17433371
Horiuchi Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 1990 PMID: 1688943

Citations for Camostat mesylate (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Camostat mesylate include:

Strobelt et al. (2022) Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism. Sci.Rep.. 12:5758
PMID: 35388061
Matsuyama et al. (2018) Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells. J Virol. 92
PMID: 30021905
Shirato et al. (2017) Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry. J Virol. 91
PMID: 27733646
Shirato et al. (2013) Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2. J Virol. 87:12552
PMID: 24027332
Gamble et al. (2013) Plasminogen activator inhibitor (PAI)-1 suppresses inhibition of gastric emptying by cholecystokinin (CCK) in mice. Leukemia. 185:41518
PMID: 23816469
Bertram et al. (2013) TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium. J Virol. 87:6150
PMID: 23536651
Kawase et al. (2012) Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry. J Virol. 86:6537
PMID: 22496216

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Customer Reviews for Camostat mesylate (1)

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Used in cell culture

Name: Irving Garcia

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: ES cells

Used in cell culture to compare with nanocamostat. Need to run qPCR for final outcome.

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