Camostat mesylate

Name: Camostat mesylate
Brand: Tocris Bioscience
SKU: 3193
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3193

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Citations (34)

COA / SDS

Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells

Key Product Details

Description:	Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells
Chemical Name:	4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	494.52

View Full Technical Details for Camostat mesylate

Technical Data
Citations / Reviews (1)

Biological Activity for Camostat mesylate

Camostat mesylate is an orally active protease inhibitor. Inhibits trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration. Also inhibits transmembrane serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (COVID-19) into lung cells in vitro.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Camostat mesylate

Camostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Camostat mesylate

M. Wt	494.52
Formula	C₂₀H₂₂N₄O₅.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	59721-29-8
PubChem ID	43071
InChi Key	FSEKIHNIDBATFG-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Camostat mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.73	50
	DMSO	49.45	100

Preparing Stock Solutions for Camostat mesylate

The following data is based on the product molecular weight 494.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.11 mL	20.22 mL
5 mM	0.40 mL	2.02 mL	4.04 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for Camostat mesylate

References are publications that support the biological activity of the product.

Ishikura The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 2007 PMID: 17433371
Hoffmann SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 2020 PMID: 32142651
Horiuchi Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 1990 PMID: 1688943