C-type natriuretic peptide (1-22) (human, rat, swine)

Name: C-type natriuretic peptide (1-22) (human, rat, swine)
Brand: Tocris Bioscience
SKU: 3520
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3520

(1)

Citations (6)

COA / SDS

Endogenous peptide agonist at NPR2

Key Product Details

Description:	Endogenous peptide agonist at NPR2
Purity:	≥95% (HPLC)
Molecular Weight:	2197.61

View Full Technical Details for C-type natriuretic peptide (1-22) (human, rat, swine)

Technical Data
Citations / Reviews (1)

Biological Activity for C-type natriuretic peptide (1-22) (human, rat, swine)

C-type natriuretic peptide (1-22) (human, rat, swine) is an endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.

Technical Data for C-type natriuretic peptide (1-22) (human, rat, swine)

M. Wt	2197.61
Formula	C₉₃H₁₅₇N₂₇O₂₈S₃
Single Letter Sequence	GLSKGCFGLKLDRIGSMSGLGC (Modifications: Disulfide bridge: 6-22)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	127869-51-6
PubChem ID	16179407
InChi Key	UHSBKBYWHCBDCJ-DYGWFTAGSA-N
Smiles	[H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C-type natriuretic peptide (1-22) (human, rat, swine)

Solubility

Soluble to 1mg/ml in water

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References for C-type natriuretic peptide (1-22) (human, rat, swine)

References are publications that support the biological activity of the product.

Pejchalova C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 2007 PMID: 17681481
Rose and Giles Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 2008 PMID: 18006579
Suga Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 1992 PMID: 1309330