C 87
Tocris Bioscience, part of Bio-Techne | Catalog # 5484
TNF-α inhibitor
Discontinued Product
5484 has been discontinued.
View all Cytokine Compounds products.
Product Description
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). Inhibits TNF-α-induced cytotoxicity in L929 fibroblast cells. Attenuates inflammation and increases survival in a mouse hepatitis model.Product Specifications
Molecular Weight
502.93
Formula
C24H15ClN6O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone]
CAS Number
332420-90-3
PubChem ID
5756872
InChI Key
VELQTEBILFDDQX-SLMZUGIISA-N
SMILES
O=C1N(C4=NC(C5=CC=CC=C5)=CS4)N=C(C3=CC=CC=C3)/C1=N/NC2=CC([N+]([O-])=O)=C(Cl)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.06 | 20 |
Preparing Stock Solutions
for C 87
The following data is based on the product molecular weight 502.93
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.94 mL | 49.71 mL | 99.42 mL |
| 1 mM | 1.99 mL | 9.94 mL | 19.88 mL |
| 2 mM | 0.99 mL | 4.97 mL | 9.94 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ma A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model. J.Biol.Chem. 2014 PMID: 24634219
Product Specific Notices for C 87
For research use only
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