C 101248

Product Description

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K⁺ channel 1 (THIK-1, IC₅₀ = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and K_v2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K⁺ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.

Solubility

Preparing Stock Solutions for C 101248

The following data is based on the product molecular weight 292.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.11 mL	34.21 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ossola Characterisation of C101248: a novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome. Neuropharmacology 2022 PMID: 36375694