Bz 423

Tocris Bioscience, part of Bio-Techne | Catalog # 5791

ATP synthase inhibitor; proapoptotic
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Key Product Details

Description

ATP synthase inhibitor; proapoptotic

View all Synthase/Synthetase Inhibitors »

Product Description

Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

Product Specifications

Molecular Weight

440.92

Formula

C27H21ClN2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one

CAS Number

216691-95-1

PubChem ID

5497206

InChI Key

IJEUIRDNQUQMFU-UHFFFAOYSA-N

SMILES

CN1C2=CC=C(C=C2C(C3=CC=C(C=C3)O)=NC(C1=O)CC4=CC5=CC=CC=C5C=C4)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.09 100
Ethanol 44.09 100

Preparing Stock Solutions for Bz 423

The following data is based on the product molecular weight 440.92

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Bz 423

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bz 423

For research use only

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