BX 430
Tocris Bioscience, part of Bio-Techne | Catalog # 5545
Selective P2X4 allosteric antagonist
Key Product Details
Description
Selective P2X4 allosteric antagonist
Product Description
BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.Product Specifications
Molecular Weight
413.11
Formula
C15H15Br2N3O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
CAS Number
688309-70-8
PubChem ID
2810999
InChI Key
JFNKIJKRXKPQCC-UHFFFAOYSA-N
SMILES
CC(C)C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.31 | 100 | |
| Ethanol | 41.31 | 100 |
Preparing Stock Solutions
for BX 430
The following data is based on the product molecular weight 413.11
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.42 mL | 12.10 mL | 24.21 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.42 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ase Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 2015 PMID: 25597706
Product Specific Notices for BX 430
For research use only
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