Bupropion hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2831
Non-selective inhibitor of dopamine and noradrenalin transporters
Key Product Details
Description
Non-selective inhibitor of dopamine and noradrenalin transporters
Product Description
Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.Product Specifications
Molecular Weight
276.20
Formula
C13H18ClNO.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
CAS Number
31677-93-7
PubChem ID
62884
InChI Key
HEYVINCGKDONRU-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(C(C(C)NC(C)(C)C)=O)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 27.62 | 100 | |
| DMSO | 27.62 | 100 |
Preparing Stock Solutions
for Bupropion hydrochloride
The following data is based on the product molecular weight 276.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.62 mL | 18.10 mL | 36.21 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 10 mM | 0.36 mL | 1.81 mL | 3.62 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Torres Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 2003 PMID: 12511858
- Dwoskin Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 2006 PMID: 17227286
- Slemmer Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 2000 PMID: 10991997
Product Specific Notices for Bupropion hydrochloride
For research use only
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