Budesonide

Name: Budesonide
Brand: Tocris Bioscience
SKU: 2671

Catalog # 2671 | Tocris Bioscience a Bio-Techne Brand

Citations (3)

COA / SDS

Synthetic glucocorticoid; anti-inflammatory and chemopreventive

Key Product Details

Description:	Synthetic glucocorticoid; anti-inflammatory and chemopreventive
Chemical Name:	(11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
Purity:	≥98% (HPLC)
Molecular Weight:	430.53

View Full Technical Details for Budesonide

Technical Data
Citations (3) / Reviews

Biological Activity for Budesonide

Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.

Compound Libraries for Budesonide

Budesonide is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Budesonide

M. Wt	430.53
Formula	C₂₅H₃₄O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	51333-22-3
PubChem ID	5281004
InChi Key	VOVIALXJUBGFJZ-KWVAZRHASA-N
Smiles	O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H]5[C@](C(CO)=O)4OC(CCC)O5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Budesonide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.05	100
	ethanol	21.52	50

Preparing Stock Solutions for Budesonide

The following data is based on the product molecular weight 430.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.61 mL	23.23 mL
5 mM	0.46 mL	2.32 mL	4.65 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Reconstitution Calculator

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References for Budesonide

References are publications that support the biological activity of the product.

Wattenberg Chemoprevention of pulmonary carcinogenesis by aerosolized budes. in female A/J mice. Cancer Res. 2007 PMID: 9407956
Pereira Modulation by budes. of DNA methylation and mRNA expression in mouse lung tumors. Int.J.Cancer 2006 PMID: 17163412
Spencer Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease. Drugs 1995 PMID: 8586030

Citations for Budesonide (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Budesonide include:

Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports. 7:39905
PMID: 28051147
Kim et al. (2016) Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Front Endocrinol (Lausanne). NULL:me20161029
PMID: 27355192
Liu et al. (2015) A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Endocrinol. 11:4121
PMID: 25672589

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