BTS

Name: BTS
Brand: Tocris Bioscience
SKU: 1870

Tocris Bioscience, part of Bio-Techne | Catalog # 1870

Citations (35)

COA / SDS

Selective inhibitor of skeletal muscle myosin II ATPase activity

Key Product Details

Description:	Selective inhibitor of skeletal muscle myosin II ATPase activity
Chemical Name:	4-Methyl-N-(phenylmethyl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	261.34

View Full Technical Details for BTS

Technical Data
Citations

Biological Activity for BTS

BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC₅₀ ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.

Compound Libraries for BTS

BTS is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BTS

M. Wt	261.34
Formula	C₁₄H₁₅NO₂S
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1576-37-0
PubChem ID	95801
InChi Key	WTHKAJZQYNKTCJ-UHFFFAOYSA-N
Smiles	CC1=CC=C(C=C1)S(=O)(=O)NCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTS

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	18.29	70
	DMSO	26.13	100

Preparing Stock Solutions for BTS

The following data is based on the product molecular weight 261.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.83 mL	19.13 mL	38.26 mL
5 mM	0.77 mL	3.83 mL	7.65 mL
10 mM	0.38 mL	1.91 mL	3.83 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

Molarity Calculator

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Reconstitution Calculator

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References for BTS

References are publications that support the biological activity of the product.

Ramachandran Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil.Cytoskeleton 2003 PMID: 12673599
Shaw Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 2003 PMID: 12755615
Cheung A small-molecule inhibitor of skeletal muscle myosin II. Nat.Cell.Biol. 2001 PMID: 11744924

BTS