BSJ-04-132
Tocris Bioscience, part of Bio-Techne | Catalog # 6937
Selective Cdk4 Degrader (PROTAC®)
Discontinued Product
6937 has been discontinued.
View all Active Degraders products.
Product Description
BSJ-04-132 is a selective Cdk4 Degrader (PROTAC®). Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
819.92
Formula
C42H49N11O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide
CAS Number
2349356-39-2
InChI Key
GWLSXEHHNOBFOI-UHFFFAOYSA-N
SMILES
O=C(COC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2=O)=O)=CC=C1)NCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC7=C(C=C(C(N(C)C)=O)N7C8CCCC8)C=N6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 81.99 | 100 |
Preparing Stock Solutions
for BSJ-04-132
The following data is based on the product molecular weight 819.92
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.22 mL | 6.10 mL | 12.20 mL |
| 5 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 10 mM | 0.12 mL | 0.61 mL | 1.22 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jiang Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 2019 PMID: 30802347
Product Specific Notices for BSJ-04-132
For research use only
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