BS 181 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5608
Selective cdk7 inhibitor
Key Product Details
Description
Selective cdk7 inhibitor
Product Description
BS 181 dihydrochloride is a selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.Product Specifications
Molecular Weight
453.45
Formula
C22H32N6.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride
CAS Number
1883548-83-1
PubChem ID
91826108
InChI Key
XYXAMTBYYTXHSO-UHFFFAOYSA-N
SMILES
CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.34 | 100 | |
| DMSO | 45.34 | 100 |
Preparing Stock Solutions
for BS 181 dihydrochloride
The following data is based on the product molecular weight 453.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.03 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ali The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 2009 PMID: 19638587
Product Specific Notices for BS 181 dihydrochloride
For research use only
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