Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (K_i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Product Specifications

Molecular Weight

905.04

Formula

C₄₇H₆₈O₁₇

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1^3,7.1^11,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester

CAS Number

83314-01-6

PubChem ID

5280757

InChI Key

MJQUEDHRCUIRLF-TVIXENOKSA-N

SMILES

O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Sun Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 2014 PMID: 24659806
Sun and Alkon Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 2006 PMID: 16834754
Wender The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 1998 PMID: 9618462
Lorenzo The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 1997 PMID: 9407126

Bryostatin 1

Tocris Bioscience, part of Bio-Techne | Catalog # 2383

Key Product Details

Description

Alternative Names

View all Protein Kinase C Activators »

Product Description