BRL 44408 maleate

Name: BRL 44408 maleate
Brand: Tocris Bioscience
SKU: 1133
Price: 201 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 1133

Citations (2)

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Key Product Details

Description:	Selective α_2A antagonist
Chemical Name:	2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
Purity:	≥98% (HPLC)
Molecular Weight:	331.37

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Biological Activity for BRL 44408 maleate

BRL 44408 maleate is a selective α_2A-adrenoceptor antagonist (K_i = 1.7 nM and 144.5 nM at α_2A and α_2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for BRL 44408 maleate

M. Wt	331.37
Formula	C₁₃H₁₇N₃.C₄H₄O₄
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	681806-46-2
PubChem ID	10382026
InChi Key	DDIQGSUEJOOQQQ-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRL 44408 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	33.14	100

Preparing Stock Solutions for BRL 44408 maleate

The following data is based on the product molecular weight 331.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for BRL 44408 maleate

References are publications that support the biological activity of the product.

Callado α_2A-But not α_2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur.J.Pharmacol. 1999 PMID: 10064149
Gavin α_2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089673
Kiss Subtype-specificity of the presynaptic α₂-adrenoceptors modulating hippocampal NE release in rat. Brain Res. 1995 PMID: 7796102
Young Novel α₂-adrenoceptor antagonists show selectivity for α_2A- and α_2B-adrenoceptor subtypes. Eur.J.Pharmacol. 1989 PMID: 2573535

Citations for BRL 44408 maleate (2)

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Citations are publications that use Bio-Techne products. Selected citations for BRL 44408 maleate include:

Rennekamp et al. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 12:552
PMID: 27239788
Backman et al. (2013) Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems. Scand J Med Sci Sports. 23:687
PMID: 22292987

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Product Documents for BRL 44408 maleate

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.