BRL 37344, sodium salt

Name: BRL 37344, sodium salt
Brand: Tocris Bioscience
SKU: 0948

Tocris Bioscience a Bio-Techne Brand

Catalog # 0948

Citations (10)

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Key Product Details

Description:	β₃ agonist
Chemical Name:	(R,R)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	385.82

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Biological Activity for BRL 37344, sodium salt

BRL 37344, sodium salt is a potent and selective β₃ adrenoceptor agonist (K_i values are 287, 1750 and 1120 nM for β₃, β₁ and β₂ receptors respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for BRL 37344, sodium salt

M. Wt	385.82
Formula	C₁₉H₂₁NO₄ClNa
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	127299-93-8
PubChem ID	16219010
InChi Key	SNJIJYKMYQRHRC-WJKBNZMCSA-M
Smiles	[Na+].C[C@H](CC1=CC=C(OCC([O-])=O)C=C1)NC[C@H](O)C1=CC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRL 37344, sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	38.58	100

Preparing Stock Solutions for BRL 37344, sodium salt

The following data is based on the product molecular weight 385.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.96 mL	25.92 mL
5 mM	0.52 mL	2.59 mL	5.18 mL
10 mM	0.26 mL	1.30 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for BRL 37344, sodium salt

References are publications that support the biological activity of the product.

Board BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 2000 PMID: 11011029
Ayo Oriowo The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 1996 PMID: 8613923
Strosberg and Pietri-Rouxel Function and regulation of the β₃-adrenoceptor. TiPS 1996 PMID: 8979772
Arch Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 1984 PMID: 6325935

Citations for BRL 37344, sodium salt (10)

Showing 1 - 10 of 10 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for BRL 37344, sodium salt include:

Lavine (2017) β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 58(1):299
PMID: 28114591
Littmann et al. (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Dev Neurosci. 355:183
PMID: 26306764
Suárez et al. (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech. 7:129
PMID: 24159189
Lavine et al. (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 131:376
PMID: 23303344
Rankovic et al. (2011) Modulation of calcium-dependent inactivation of L-type Ca²⁺ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One. 6:e27474
PMID: 22164209
Maupoil et al. (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol. 150:899
PMID: 17325650
Briones et al. (2005) Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries. Br J Pharmacol. 146:679
PMID: 16113691
Brahmadevara et al. (2004) ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. Br J Pharmacol. 142:781
PMID: 15205310
Cirino et al. (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. J Biol Chem. 100:5531
PMID: 12707413
Steinle et al. (2003) β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Pharmacol Exp Ther. 278:20681
PMID: 12670949

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