BRL 37344, sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 0948
β3 agonist
Product Description
BRL 37344, sodium salt is a potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively).Licensing Information
Sold with the permission of GlaxoSmithKlineProduct Specifications
Molecular Weight
385.82
Formula
C19H21NO4ClNa
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
CAS Number
127299-93-8
PubChem ID
16219010
InChI Key
SNJIJYKMYQRHRC-WJKBNZMCSA-M
SMILES
[Na+].C[C@H](CC1=CC=C(OCC([O-])=O)C=C1)NC[C@H](O)C1=CC(Cl)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 38.58 | 100 |
Preparing Stock Solutions
for BRL 37344, sodium salt
The following data is based on the product molecular weight 385.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.59 mL | 12.96 mL | 25.92 mL |
| 5 mM | 0.52 mL | 2.59 mL | 5.18 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.59 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Strosberg and Pietri-Rouxel Function and regulation of the β3-adrenoceptor. TiPS 1996 PMID: 8979772
- Ayo Oriowo The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344. J.Pharmacol.Exp.Ther. 1996 PMID: 8613923
- Board BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro. Eur.J.Pharmacol. 2000 PMID: 11011029
- Arch Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 1984 PMID: 6325935
Product Specific Notices for BRL 37344, sodium salt
For research use only
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