Brivaracetam
Tocris Bioscience, part of Bio-Techne | Catalog # 7271
SV2A ligand; antiepileptic
Key Product Details
Description
SV2A ligand; antiepileptic
Product Description
Brivaracetam is an antiepileptic compound that is a ligand for synaptic vesicle glycoprotein 2A (SV2A; Kd = 50 nM for human SV2A in vitro). Brivaracetam displays selectivity for SV2A at 10 μM, against a panel of 55 receptors, enzymes, ion channels and transporters. In mice, Brivaracetam protects against clonic audiogenic seizures.Product Specifications
Molecular Weight
212.29
Formula
C11H20N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(αS,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide
CAS Number
357336-20-0
PubChem ID
9837243
InChI Key
MSYKRHVOOPPJKU-BDAKNGLRSA-N
SMILES
CCC[C@H]1CN(C(C1)=O)[C@H](C(N)=O)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.23 | 100 | |
| DMSO | 21.23 | 100 |
Preparing Stock Solutions
for Brivaracetam
The following data is based on the product molecular weight 212.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.71 mL | 23.55 mL | 47.11 mL |
| 5 mM | 0.94 mL | 4.71 mL | 9.42 mL |
| 10 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rogawski A new SV2A ligand for epilepsy. Cell. 2016 PMID: 27768878
- Gillard Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur.J.Pharmacol. 2011 PMID: 21575627
Product Specific Notices for Brivaracetam
For research use only
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