Brivaracetam

Name: Brivaracetam
Brand: Tocris Bioscience
SKU: 7271

Tocris Bioscience a Bio-Techne Brand

Catalog # 7271

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Key Product Details

Description:	SV2A ligand; antiepileptic
Chemical Name:	(αS,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	212.29

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Biological Activity for Brivaracetam

Brivaracetam is an antiepileptic compound that is a ligand for synaptic vesicle glycoprotein 2A (SV2A; K_d = 50 nM for human SV2A in vitro). Brivaracetam displays selectivity for SV2A at 10 μM, against a panel of 55 receptors, enzymes, ion channels and transporters. In mice, Brivaracetam protects against clonic audiogenic seizures.

Technical Data for Brivaracetam

M. Wt	212.29
Formula	C₁₁H₂₀N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	357336-20-0
PubChem ID	9837243
InChi Key	MSYKRHVOOPPJKU-BDAKNGLRSA-N
Smiles	CCC[C@H]1CN(C(C1)=O)[C@H](C(N)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Brivaracetam

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	21.23	100
	water	21.23	100

Preparing Stock Solutions for Brivaracetam

The following data is based on the product molecular weight 212.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.71 mL	23.55 mL	47.11 mL
5 mM	0.94 mL	4.71 mL	9.42 mL
10 mM	0.47 mL	2.36 mL	4.71 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

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References for Brivaracetam

References are publications that support the biological activity of the product.

Rogawski A new SV2A ligand for epilepsy. Cell. 2016 PMID: 27768878
Gillard Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur.J.Pharmacol. 2011 PMID: 21575627

Citations for Brivaracetam

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