Brequinar sodium
Tocris Bioscience, part of Bio-Techne | Catalog # 6196
Potent and selective DHODH inhibitor
Key Product Details
Description
Potent and selective DHODH inhibitor
Alternative Names
BRQ,DuP 785,NSC 368390
Product Description
Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of >400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 μM. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo. Antimetabolite.Product Specifications
Molecular Weight
397.35
Formula
C23H14F2NO2Na
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium
CAS Number
96201-88-6
PubChem ID
23663964
InChI Key
PZOHOALJQOFNTB-UHFFFAOYSA-M
SMILES
CC1=C(C2=CC(F)=CC=C2N=C1C3=CC=C(C4=C(C=CC=C4)F)C=C3)C(O[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 39.73 | 100 | |
| DMSO | 39.73 | 100 |
Preparing Stock Solutions
for Brequinar sodium
The following data is based on the product molecular weight 397.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.52 mL | 12.58 mL | 25.17 mL |
| 5 mM | 0.50 mL | 2.52 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sykes Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia. Cell 2016 PMID: 27641501
- Peters Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390). Invest.New Drugs 1987 PMID: 2822596
- Arteaga Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390). Cancer Res. 1989 PMID: 2743343
Product Specific Notices for Brequinar sodium
For research use only
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