BQ-123

Tocris Bioscience, part of Bio-Techne | Catalog # 1188

COA / SDS

Selective ETA antagonist

Key Product Details

Description:	Selective ET_A antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	611

View Full Technical Details for BQ-123

Technical Data
Citations

Biological Activity for BQ-123

BQ-123 is a selective ET_A endothelin receptor antagonist (K_i values are 1.4 and 1500 nM at ET_A and ET_B receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.

Technical Data for BQ-123

M. Wt	611
Formula	C₃₁H₄₂N₆O₇
Single Letter Sequence	WDPVL (Modifications: Trp-1 = D-Trp, Asp-2 = D-Asp, Val-4 = D-Val, Cyclized)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	136553-81-6
PubChem ID	52943236
InChi Key	VYCMAAOURFJIHD-AOYLRGCGSA-N
Smiles	CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BQ-123

Solubility

Soluble to 0.4mg/ml in water

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References for BQ-123

References are publications that support the biological activity of the product.

Sakamoto Distinct subdomains of human endothelin receptors determine their selectivity to endothelin_A-selective antagonist and endothelin_B-selective agonists. J.Biol.Chem. 1993 PMID: 8473300
Ekelund Effects of selective ET_B-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 1994 PMID: 7921617
Makatani Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics. Eur.J.Pharmacol. 2000 PMID: 11011045
Agapitov and Haynes Role of endothelin in cardiovascular disease. J.Renin Angiotensin Aldosterone Syst. 2002 PMID: 11984741