BQ-123
Tocris Bioscience, part of Bio-Techne | Catalog # 1188
Selective ETA antagonist
Key Product Details
Description
Selective ETA antagonist
Product Description
BQ-123 is a selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). Reduces ischemia-induced ventricular arrhythmias in a rat model.Product Specifications
Molecular Weight
611.00
Formula
C31H42N6O7
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
136553-81-6
PubChem ID
52943236
InChI Key
VYCMAAOURFJIHD-AOYLRGCGSA-N
SMILES
CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC1=O)C(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 0.4mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sakamoto Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 1993 PMID: 8473300
- Ekelund Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 1994 PMID: 7921617
- Makatani Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics. Eur.J.Pharmacol. 2000 PMID: 11011045
- Agapitov and Haynes Role of endothelin in cardiovascular disease. J.Renin Angiotensin Aldosterone Syst. 2002 PMID: 11984741
Product Specific Notices for BQ-123
For research use only
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